5-Amino-1MQ: Investigating the Bioenergetics of NNMT Inhibition

5-Amino-1MQ is a highly selective, membrane-permeable molecule designed to address metabolic dysfunction at the enzymatic level. By targeting NNMT—an enzyme highly expressed in adipose tissue and linked to insulin resistance—this compound allows researchers to explore how shifting cellular metabolism away from fat storage toward energy utilization can impact systemic health. When sourcing from Peptide Science, researchers receive a compound engineered for high bioavailability and consistent experimental outcomes.

Mechanism of Action: The NNMT-NAD+ Axis

The primary research value of 5-Amino-1MQ lies in its ability to modulate the nicotinamide metabolic pathway. NNMT typically consumes nicotinamide, preventing its conversion into NAD+. By inhibiting this enzyme, 5-Amino-1MQ facilitates:

• Intracellular NAD+ Elevation: Supporting DNA repair, sirtuin (SIRT1) activity, and healthy cellular aging.

• Mitochondrial Biogenesis: Enhancing the efficiency of the electron transport chain and increasing the basal metabolic rate of adipocytes.

• Glut-4 Translocation: Researching improved glucose uptake and the reduction of fasting insulin levels in metabolic syndrome models.

Primary Research Vectors

• Visceral Adiposity: Studying the reduction of white adipose tissue (WAT) and the shrinkage of fat cell size without altering caloric intake in animal models.

• Muscle Tissue Preservation: Investigating the muscle-sparing effects of NNMT inhibition during periods of significant fat oxidation.

• Anti-Inflammatory Signaling: Researching the reduction of C-reactive protein (CRP) and other markers of chronic metabolic inflammation.

• Neuroprotection: Exploring the role of increased NAD+ and mitochondrial integrity in supporting cognitive focus and neuronal resilience.

Technical Specifications

• Molecular Formula: C10​H11​N2+​

• Molecular Weight: $159.21\text{ g/mol}$

• Purity: $\ge 99\%$ (HPLC-MS Verified)

• Storage: Store at 20°C in a cool, dry place; avoid direct sunlight and humidity.

Reconstitution and Dosage Guide

As an oral small molecule, 5-Amino-1MQ in research is typically utilized in oral delivery formats. For laboratories conducting in vitro or specialized in vivo studies requiring liquid solution:

• Diluent: Use deionized water or a physiological saline solution for solubility.

• Solubility: 5-Amino-1MQ is highly soluble in aqueous solutions; gentle agitation is sufficient for complete dissolution.

• Research Concentration: In murine models, daily research dosages typically range from 20mg/kg to 30mg/kg of body weight to assess metabolic shifts over a 4–6 week cycle.

The Peptides Sciences Quality Mandate

In the current landscape of digital marketing and research supply, Peptides Science maintains technical authority by providing fully transparent laboratory data.

• Independent Verification: Every batch is tested to confirm the absence of heavy metals and cross-contaminants.

• Authenticity: Secure your data with reagents that match the exact molecular profile required for peer-reviewed publication.

• Logistics: Fast, discreet shipping ensures your 15mg 5-Amino-1MQ arrives with its structural integrity fully intact.

Note: 5-Amino-1MQ is provided for Laboratory Research Use Only. It is not intended for human or animal consumption. Please ensure all safety and handling protocols are strictly followed in your facility.