B7-33 (Relaxin Analog) 6mg

B7-33: Investigating the Targeted Anti-Fibrotic Action of Relaxin Analogs

B7-33 represents a significant breakthrough in the study of fibrotic diseases and tissue repair. While naturally occurring H2-relaxin has long been recognized for its ability to regulate connective tissue, its complex two-chain structure made it difficult to replicate and study in a stable format. Researchers who buy B7-33 online through Peptide Science are utilizing a highly soluble, 2016-engineered B-chain derivative that selectively targets the RXFP1 receptor to trigger therapeutic tissue remodeling without the side effects associated with earlier relaxin research.

Primary Research Class: Anti-Fibrotic & Tissue Remodeling Agent

B7-33 is studied for its unique ability to halt and potentially reverse fibrosis—the pathological buildup of excess connective tissue—in the heart, lungs, kidneys, and liver. It is a critical reagent for mapping how synthetic ligands can influence organ function and cellular survival.

The Mechanism: Selective pERK Signaling and MMP-2 Activation

The technical authority of B7-33 stems from its specialized signaling pathway, which differs from naturally occurring relaxin:

• Targeted RXFP1 Binding: B7-33 exhibits a high affinity for the Relaxin Family Peptide Receptor 1 (RXFP1). Unlike endogenous relaxin, which often acts via the cAMP pathway (potentially linked to tumor growth), B7-33 is studied for its preference for the pERK (extracellular signal-regulated kinase) pathway.

• MMP-2 Upregulation: Activation of the pERK pathway by B7-33 is hypothesized to stimulate the synthesis of Matrix Metalloproteinase-2 (MMP-2). This enzyme is responsible for breaking down excess collagen and extracellular matrix proteins that cause organ stiffness.

• Inhibition of Fibroblast Differentiation: Research suggests the peptide prevents the transformation of healthy cells into myofibroblasts, the primary cells responsible for laying down scar tissue.

• Vasodilation & Blood Flow: By mimicking H2-relaxin, B7-33 is also investigated for its ability to increase blood flow and reduce vascular resistance in heart failure research models.

Key Research Applications

• Cardiac & Renal Fibrosis: Studying the prevention of scar tissue formation in the heart and kidneys following chronic stress or injury.

• Tissue Remodeling: Investigating the enzymatic breakdown of the extracellular matrix to restore organ elasticity and function.

• Vascular Function: Researching the peptide’s impact on systemic hemodynamics and its potential to mitigate hypertension-related damage.

• Reproductive & Musculoskeletal Systems: Exploring the role of RXFP1 signaling in sperm motility, testicular development, and ligament flexibility.

Technical Specifications

• Molecular Formula: C131​H228​N40​O37​S

• Molecular Weight: $2987.75\text{ g/mol}$

• Purity: $\ge 99\%$ (HPLC-MS Verified)

• Other Titles: (B7-33)H2, GTPL9321

• Storage: Store at -20°C for long-term stability. Avoid repeated freeze-thaw cycles to preserve the integrity of the single-chain sequence.

Reconstitution & Dosage Guide

B7-33 6mg is provided as a highly stable, lyophilized powder engineered specifically for superior solubility compared to traditional relaxin:

• Mixing: Reconstitute with sterile Bacteriostatic Water or physiological saline.

• Preparation: Add the diluent slowly. Due to its engineered structure, B7-33 dissolves rapidly into a clear, bioactive solution.

• Research Concentration: In preclinical models investigating chronic organ fibrosis, researchers often utilize daily or continuous delivery methods to maintain consistent RXFP1 receptor saturation.

• Stability: Once reconstituted, store the solution at 4°C and use within the duration of the experimental protocol to ensure maximum anti-fibrotic activity.

Why Source from Peptides Sciences?

Fibrosis research requires peptides with absolute structural fidelity. Peptides Sciences ensures your B7-33 matches the specific 2016 modification required to bypass cAMP-mediated risks.

• 99% Purity Guaranteed: We utilize independent HPLC and Mass Spectrometry to confirm the purity and amino acid sequence of every 6mg vial.

• High-Authority Standards: Our peptides are manufactured for structural consistency, ensuring your data on the pERK pathway remains accurate and reproducible.

• Full Transparency: Every order includes a batch-specific Certificate of Analysis (COA).

• Secure Logistics: Fast, discreet shipping ensures your research materials arrive in optimal condition for immediate laboratory use.

Note: B7-33 is provided for Laboratory Research Use Only. It is not intended for human or animal consumption. Please ensure all safety and handling protocols are strictly followed in your facility.