AICAR 50mg

AICAR: Investigating the Bioenergetic Impact of Synthetic AMPK Activation

AICAR is a foundational reagent in the study of cellular energy homeostasis. By acting as an analog to AMP, AICAR binds to the $y$-subunit of AMPK, tricking the cell into a “low energy” state. This triggers a systemic shift in metabolism, prioritizing the survival and energy production of the cell. Researchers who buy AICAR online through Peptide Science are exploring a vast landscape of applications, from treating metabolic syndrome to enhancing the mitochondrial density of skeletal muscle.

Primary Research Class: Metabolic Regulator & Exercise Mimetic

AICAR is unique because it stimulates the same metabolic pathways activated during high-intensity aerobic exercise. It is a critical reagent for studying the “couch to 5k” effect at a molecular level, investigating how chemical signaling can replicate the benefits of physical movement.

The Mechanism: Mastering the AMPK Energy Switch

The biological authority of AICAR stems from its precise interaction with the AMPK enzyme, the body’s “master metabolic switch”:

• Activation of Catabolism: AICAR signals the body to accelerate the breakdown of glucose and fatty acids. This process generates ATP, providing a rapid increase in available cellular energy.

• Inhibition of Anabolism: To preserve energy, AICAR is studied for its ability to temporarily “turn off” energy-consuming pathways, such as the synthesis of new proteins and fatty acids.

• Mitochondrial Biogenesis: Research suggests that AICAR triggers the creation of new mitochondria, increasing the oxidative capacity of skeletal muscle and improving overall endurance in experimental models.

• Glucose Uptake & Insulin Sensitivity: By stimulating the GLUT4 transporter, AICAR is investigated for its ability to move sugar from the bloodstream into the muscles without the need for insulin, making it a high-priority compound for prediabetes research.

Key Research Applications

• Metabolic Disorder Mitigation: Studying the reversal of insulin resistance and the management of Type 2 Diabetes models.

• Ischemic Reperfusion Injury: Investigating how AICAR protects tissues by maintaining energy levels during a loss of blood flow (ischemia) and the subsequent return of oxygen.

• Physical Performance Enhancement: Mapping the increase in fat oxidation and aerobic capacity in animal models.

• Autophagy & Cellular Longevity: Researching the AMPK-mediated “clearing out” of damaged cellular components to promote healthy aging.

Technical Specifications

• Molecular Formula: C9​H15​N4​O8​P

• Molecular Weight: $338.21\text{ g/mol}$

• Purity: $\ge 99\%$ (HPLC-MS Verified)

• CAS Number: 2627-69-2

• Storage: Store at -20°C for long-term stability. Protect from light and moisture to prevent degradation of the nucleotide structure.

Reconstitution & Dosage Guide

AICAR 50mg is provided as a highly stable, lyophilized powder. Precision in preparation is vital for metabolic accuracy:

• Mixing: Reconstitute with sterile Bacteriostatic Water or physiological saline.

• Preparation: Add the diluent gently and swirl. AICAR is highly soluble and should result in a perfectly clear solution.

• Research Concentration: In murine endurance studies, dosages often range from 125mg/kg to 500mg/kg of body weight to assess systemic shifts in energy utilization.

• Note on Half-Life: AICAR has a relatively short half-life in vivo; many research protocols utilize daily administration to maintain AMPK activation.

Why Source from Peptides Sciences?

Metabolic research requires reagents with absolute chemical identity. Peptides Sciences maintains technical authority by providing the most rigorously tested AICAR on the market.

• 99% Purity Guaranteed: We utilize independent HPLC and Mass Spectrometry to confirm the purity and weight of every 50mg vial.

• Authentic Bioactivity: Our AICAR is manufactured to ensure immediate permeability and maximum affinity for the AMPK enzyme.

• Full Transparency: Every order includes a batch-specific Certificate of Analysis (COA).

• Discreet Logistics: Fast, secure shipping ensures your research materials arrive with their bioenergetic potential fully intact.

Note: AICAR is provided for Laboratory Research Use Only. It is not intended for human or animal consumption. Please ensure all safety and handling protocols are strictly followed in your facility.