ARA-290 Peptide 16mg

ARA-290: Investigating the Non-Erythropoietic Pathways of Tissue Protection

ARA-290, also known as Helix B Surface Peptide (HBSP), represents a breakthrough in the study of cytoprotection. By isolating the tissue-protective domain of erythropoietin from its blood-building domain, researchers can explore the regenerative potential of the EPO system without the risk of increased blood viscosity. Researchers who buy ARA-290 online through Peptide Science are focusing on its high affinity for the Innate Repair Receptor (IRR)—a heterocomplex consisting of the EPO receptor and the beta common receptor (CD131) that is expressed specifically during tissue stress and injury.

Primary Research Class: Neuroprotective & Anti-Inflammatory Agent

ARA-290 is uniquely positioned in clinical research for its ability to “silence” the inflammatory alarm system of the body. It is an essential reagent for mapping the transition from acute tissue injury to chronic neuropathic states.

The Mechanism: Activating the Innate Repair Receptor (IRR)

The technical authority of ARA-290 stems from its selective paracrine signaling, which triggers a cascade of protective cellular events:

• Selective IRR Binding: ARA-290 binds to the Innate Repair Receptor (IRR) that appears on the surface of cells following trauma, ischemia, or metabolic stress.

• Suppression of Pro-inflammatory Cytokines: Research suggests the peptide significantly inhibits the production of TNF-alpha and Interleukin-6 (IL-6), effectively dampening the “cytokine storm” in experimental models.

• Anti-Nociceptive Action: By protecting small nerve fibers and reducing neuroinflammation, ARA-290 is studied for its ability to modulate allodynia and chronic neuropathic pain.

• Metabolic Stabilization: In diabetic research models, ARA-290 has been shown to improve glucose metabolism, leading to measurable reductions in HbA1c and improved cholesterol profiles.

Key Research Applications

• Neuropathic Pain & Sarcoidosis: Investigating the restoration of small nerve fiber density and the mitigation of chronic pain signaling.

• Wound Repair & Regeneration: Studying the acceleration of dermal healing and tissue structural integrity following severe injury.

• Metabolic Syndrome Research: Mapping the peptide’s influence on insulin sensitivity and lipid profiles in obesity-related studies.

• Ischemic Protection: Researching the prevention of cell death (apoptosis) in organs subjected to oxygen deprivation or reperfusion injury.

Technical Specifications

• Molecular Formula: C51​H54​N16​O21​

• Molecular Weight: $1257.3\text{ g/mol}$

• Purity: $\ge 99\%$ (HPLC-MS Verified)

• Amino Acid Sequence: Derived from the Beta domain of Erythropoietin.

• Storage: Store at -20°C for long-term stability. Protect from light and avoid multiple freeze-thaw cycles.

Reconstitution & Dosage Guide

ARA-290 is provided as a highly stable, lyophilized powder. Precision in preparation is critical for maintaining its selective binding affinity:

• Mixing: Reconstitute with sterile Bacteriostatic Water or physiological saline.

• Preparation: Slowly add the diluent down the side of the vial and gently swirl. The solution should be crystal clear.

• Research Concentration: In clinical research models for neuropathy, dosages are often calculated based on the frequency required to maintain consistent Innate Repair Receptor activation during the inflammatory phase.

• Stability: Once reconstituted, the solution should be stored at 4°C and used within the experimental timeframe to ensure maximum potency.

Why Source from Peptides Sciences?

In high-level neuroprotective research, sequence accuracy is paramount. Peptides Sciences ensures that your ARA-290 is free from erythropoietic contaminants that could skew your data.

• 99% Purity Guaranteed: We utilize independent HPLC and Mass Spectrometry to confirm the purity and sequence of every batch.

• High-Authority Documentation: Every purchase includes a batch-specific Certificate of Analysis (COA).

• Bioactive Integrity: Our advanced lyophilization process ensures that the peptide remains in its most stable, bioactive form.

• Secure Logistics: Fast, discreet shipping ensures your research materials arrive with their molecular structure fully intact.

Note: ARA-290 is provided for Laboratory Research Use Only. It is not intended for human or animal consumption. Please ensure all safety and handling protocols are strictly followed in your facility.